Acarbose Encapsulation in Guar Gum Nanoparticles for Enhanced Anti-Diabetic Activity
Problem: Acarbose, an anti-diabetic drug, suffers from poor bioavailability and requires high doses to achieve therapeutic effects, often leading to gastrointestinal side effects. This limits its efficacy and patient compliance. Implemented Solution: The encapsulation of Acarbose in Guar Gum nanoparticles aims to improve its bioavailability, enhance its therapeutic effects, and reduce side effects. Guar Gum, a natural polysaccharide, offers biocompatibility and controlled release properties, making it an ideal carrier for Acarbose. The nanoparticles are designed to protect Acarbose from degradation, ensuring its gradual release and sustained anti-diabetic activity.
Biotechnology And National Health
Technologies for human health
The estimated duration for full implementation, including research, clinical trials, regulatory approval, and market launch, is approximately 5-7 years.
ilot studies and initial commercialization will focus on urban centers with high prevalence of Type 2 diabetes
Enhanced Bioavailability: Improved absorption and sustained release of Acarbose, leading to better glycemic control. Reduced Side Effects: Lower doses required to achieve therapeutic effects, minimizing gastrointestinal discomfort. Biocompatibility: Use of Guar Gum, a natural and safe polysaccharide, ensures minimal toxicity. Controlled Release: Nanoparticle encapsulation allows for the controlled release of Acarbose, providing consistent therapeutic levels over time. Patient Compliance: Improved efficacy and reduced side effects lead to higher patient adherence to treatment.
The complete list of publication can be observed at https://pubmed.ncbi.nlm.nih.gov/?term=Jeena+Gupta&sort=date and https://scholar.google.com/citations?hl=en&user=rD28XZwAAAAJ&view_op=list_works&sortby=pubdate
Guar gum-based nanoformulations: Implications for improving drug delivery. Garg SS, Gupta J. Int J Biol Macromol. 2023 Feb 28;229:476-485. doi: 10.1016/j.ijbiomac.2022.12.271.
