Integrating Network Pharmacology and Molecular Docking approach to elucidate the mechanism of Terminalia chebula for the treatment of Rheumatoid Arthritis
Rheumatoid Arthritis (RA) is a chronic autoimmune disorder characterized by inflammation, pain, and swelling in the joints, leading to joint destruction and disability. Terminalia chebula, a well-known medicinal plant, has been traditionally used in Ayurvedic medicine for its anti-inflammatory and antioxidant properties. Implemented Solutions: To elucidate the mechanism of action of Terminalia chebula in the treatment of RA, an integrated network pharmacology and molecular docking approach was employed. The following steps are required such as Identification of Bioactive Compounds, Target Prediction, Network Pharmacology Analysis, Pathway Enrichment Analysis, Molecular Docking Studies and Validiation
Biotechnology And National Health
Technologies for human health
2-3 months
Asia a. India: Key cities with prominent research institutions and pharmaceutical industries, such as Mumbai, Bangalore, and Hyderabad. Regions with a strong tradition of Ayurvedic medicine and widespread use of Terminalia chebula. b. China: Cities with leading research universities and traditional Chinese medicine (TCM) institutions, such as Beijing, Shanghai, and Guangzhou. Areas where herbal medicine is integrated into mainstream healthcare practices. c. Japan: Cities with advanced research facilities and a history of using Kampo medicine, such as Tokyo, Kyoto, and Osaka. Regions with interest in integrating traditional remedies with modern medicine.
The integrated approach of network pharmacology and molecular docking for elucidating the mechanism of Terminalia chebula in the treatment of rheumatoid arthritis offers several competitive advantages: Comprehensive Mechanistic Insight: Evidence-Based Validation: Identification of Bioactive Compounds: Enhanced Drug Discovery: Reduction of Side Effects: Cost-Effective Research and Development: Synergistic Therapeutic Potential: Alignment with Traditional Medicine: Personalized Medicine: Regulatory and Market Advantages:
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