Research on the design of medical magnesium alloy implants based on laser additive manufacturing
Diseases of the skeletal system, such as fractures, bone defects, and joint diseases, bring great suffering to patients and impose heavy economic and living burdens on society and families. Bone defect repair remains a major challenge in clinical orthopedics. In recent years, biodegradable metals like magnesium and its alloys have garnered significant attention due to their excellent biocompatibility, degradability, and unique bone bioactivity. Magnesium ions, as essential elements for the human body, can induce osteoblast differentiation and mineralization within physiological concentration ranges, promoting new bone formation. Meanwhile, magnesium alloys degrade slowly in the body, gradually transferring biomechanical loads and eventually being replaced by new bone tissue, achieving good integration with bone tissue. Therefore, this project proposes the use of laser additive manufacturing to design and fabricate new magnesium alloy bone implants with excellent bioactivity and osseointegration. The aim of t
Biotechnology And National Health
Technologies for human health
2 years
China, Chongqing, Changsha
1.Bionic Design Principles and Parametric Modeling for Functional Partitioning This project will study the coupling law between natural bone structure and function, and reveal the intrinsic interaction mechanism between the formation process of new bone and the multi-scale structural topology and mechanical properties of bone. This innovation lies in the internalization of biological laws into the principle of bionic design, and the precise structural and functional mapping with natural bone is truly realized through the parametric modeling of functional partitioning. 2.Optimization of Mechanical Transfer and Transport Behavior in Heterogeneous Interfacial Regions Traditional bone repair implant design pays more attention to macroscopic mechanical properties, ignoring the important influence of microstructural characteristics of heterogeneous interface regions on cell behavior and osseointegration. This project will focus on the study of stress/strain distribution and transfer behavior inside the heterogeneous interface region, as well as the influence mechanism on biomolecular transport and protein adsorption, etc., and establish a multi-field coupled mathematical model. The innovation lies in the in-depth attention to the microscopic behavior of the heterogeneous interfacial region, and the coupling of the mechanical environment and the biomolecular transport behavior, which will provide the implant with excellent bioactivity and osseointegration capability. 3. Magnesium alloy bone implants promote the healing of bone defect sites Magnesium alloy has the advantages of low density, low modulus of elasticity, biodegradability, high specific strength, and good biocompatibility, etc. As a candidate material for biodegradable implantable devices, it shows great application prospects in orthopedic, cardiovascular, and other medical fields. Osteoinductive activity Existing studies have shown that magnesium alloy can interact with various cells in different ways at different stages of bone healing to achieve comprehensive regulation of bone healing, which not only has a special bidirectional regulation of immune response, especially macrophage polarization behavior, but also participates in the generation of vascular regeneration-related factors including hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF) and so on, It is also involved in the whole process of vascular regeneration, including the production of vascular regeneration-related factors such as hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), degradation of vascular basement membranes, proliferation and migration of endothelial cells, tube formation, and stabilization of vascular maturation, thus regulating the whole process of vascular regeneration, and thus facilitating the healing of the bone.
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Papers: Design exploration of staggered hybrid minimal surface magnesium alloy bone scaffolds; A comparative study on WE43 magnesium alloy fabricated by laser powder bed fusion coupled with deep cryogenic treatment: Evolution in microstructure and mechanical properties; Superstrengthening effect of beyond-solid-solution laser powder bed fused WE43 magnesium alloy triggered by direct aging treatment. Patents: A high strength and toughness preparation method of laser powder bed fused magnesium rare earth alloys based on deep-cooling treatment; An Additive Manufacturing-Based Design Method for Directional Deformation Hybrid TPMS Structures.
