Development of technology for obtaining functional materials for medical purposes based on bacterial cellulose
Research in the field of bacterial polymer biosynthesis opens up new possibilities for creating bacterial strains and optimizing biopolymer production processes for industry and medicine. These materials, biocompatible and non-toxic, have wide application in medical devices, such as tissue engineering scaffolds and drug delivery systems. Bacterial cellulose (BC) is of particular interest due to its unique properties, including high porosity and water-holding capacity, which makes it suitable for use in wound dressings and other medical purposes. In this regard, we have developed a technological process, the implementation of which allows us to obtain microgels, pastes, plates based on bacterial cellulose, alginate, chitosan, etc., capable of delivering drugs to the desired point in the body, as well as preserving and releasing drugs at a certain rate. The gel structures obtained during the study were based on bacterial cellulose and other biocompatible polysaccharides with immobilized probiotic bacteria L. plantarum and bacteriocins isolated from the culture liquid. Their antimicrobial activity, high sorption capacity and resistance to adverse factors were proven. It was shown that the obtained structures at acidic pH values (simulating stomach conditions) retained their integrity, and at pH values above 6.0 (simulating intestinal conditions) they completely or partially disintegrated.
Biotechnology And National Health
Preparations production, including production of microbiological preparations
24 месяца
Pharmaceutical enterprises of the Republic of Mordovia and the Russian Federation
Although numerous hydrogel-based dressings are already on the market, new wound treatment options are needed to address the growing number of severe, acute, and chronic wounds that modern society faces. High costs, safety concerns associated with drug and material use, and problems inherent to hydrogels such as lack of mechanical stability have hampered the implementation of many new materials. The development of new hydrogel dressings that overcome these shortcomings would be desirable to meet clinical needs.
Project manager V.V. Revin has many awards and titles: Honored Scientist of Russia and the Republic of Mordovia, "Excellent Student of the Higher School of Russia", "Honored Worker of Higher Education of the Russian Federation". He was awarded the gold medal of the Russian Academy of Architecture and Construction, is a member of the Russian Federal University of Management and Education and the Executive Committee of the European Biotechnology Association, and is also a member of the editorial boards of international journals
patents, 5 scientific papers
